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Certain medications such as Metformin, H2-receptor antagonists including Zantac (Ranitidine), Tagamet(Cimetedine), Famotidine, Pepcid AC (Oral Pepcid), Axid AR (Nizatidine), Proton pump inhibitors (PPIs)including Prilosec (Omeprazole), Nexium (Esomeprazole), Prevacid (Lanzoprazole) and Antacids e.g:Gaviscon can also affect your ability to absorb vitamin B12

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(PubMed) Blumberg J

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Atkins GJ, Haynes DR, Howie DW, Findlay DM (2011) Role of polyethylene particles in peri-prosthetic osteolysis: a review

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And it does not raise IGF-1, by design [3]

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